Link Kiwi (easier Python+Gtk with MVC)

Kiwi consists of a set of classes and wrappers for PyGTK that were developed to provide a sort of framework for applications. Fully object-oriented, and roughly Smalltalk's MVC, Kiwi provides a simple, practical way to build forms, windows and widgets that transparently access and display your object data.

see also
pigg Python Interface Generator for Gtk (pigg) provides a pygtk implementation of the MVC pattern.